TABLE 2.
Accuracy of vancomycin susceptibility test results (2014) to infer susceptibility to oritavancin at U.S. FDA-approved breakpoints (14) for indicated Gram-positive species groups (10,002 isolates)
| Species | No. of isolates tested | Surrogate accuracy (% [no. of nonsusceptible isolates]) |
|---|---|---|
| S. aureusa | 5,609 | >99.9 (3) |
| CoNSb | 641 | 100.0 (0) |
| β-Hemolytic streptococcia | 1,049 | 99.2 (8) |
| S. anginosus groupa | 178 | 100.0 (0) |
| S. pneumoniaeb | 1,673 | 100.0 (0) |
| Enterococcia | 852 | 100.0 (0) |
| Overalla | 7,688 | 99.86 (11) |
a
Includes the indicated species (Staphylococcus aureus, Streptococcus pyogenes, S. agalactiae, S. dysgalactiae, S. anginosus, S. constellatus, S. intermedius, and vancomycin-susceptible E. faecalis among all enterococci).
b
S. aureus interpretive criteria (susceptible, [0.12 μg/ml) were applied to coagulase-negative staphylococci (CoNS) and pneumococci for the vancomycin surrogate test comparison only; no errors were observed.