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Antimicrobial activity of β-lactam agents in combination with various concentrations of OP0595 against five strains of CTX-M-15-positive E. coli (A) and five strains of KPC-positive K. pneumoniae (B). A MIC of >128 μg/ml was counted as 256 μg/ml in calculating the geometric mean and a MIC of ≤0.008 as 0.008 μg/ml.
