FIG 3.

Comparison of the efficacies of sole and combined administration of β-lactam agents in a neutropenic murine model of thigh infection with CTX-M-15-positive E. coli (A) and KPC-positive K. pneumoniae (B). Abbreviations: FEP, cefepime; TID, three times a day. Six mice per group were rendered neutropenic, and 6.28 log₁₀ CFU/mouse of E. coli MSC20653, 6.10 log₁₀ CFU/mouse of E. coli MSC20662, 5.60 log₁₀ CFU/mouse of K. pneumoniae ATCC BAA-1705, or 5.49 log₁₀ CFU/mouse of K. pneumoniae ATCC BAA-1904 was injected into the thigh, followed by subcutaneous administration of the test compounds at 1, 3, and 5 h after infection. The mean log₁₀ CFU per thigh recovered from the infected thigh after 24 h is shown; error bars represent the SD. A P value of <0.05 indicates significance relative to the untreated control (vehicle) and is indicated by an asterisk (*) or a hash mark (#).