TABLE 1.

In vitro antibacterial activity of cefepime and OP0595 against CTX-M-15-positive E. coli and KPC-positive K. pneumoniae

Organism	β-Lactamase	MIC (μg/ml)
		OP0595	Cefepime	Cefepime-OP0595a
E. coli MSC20613	CTX-M-15	2	>64	≤0.004
E. coli MSC20627	CTX-M-15	2	>64	≤0.004
E. coli MSC20653	CTX-M-15, OXA-1	2	>64	≤0.004
E. coli MSC20662	CTX-M-15	2	>64	≤0.004
E. coli MSC20670	CTX-M-15, OXA-1	1	>64	≤0.004
K. pneumoniae ATCC BAA-1705	KPC-2	2	>64	≤0.004
K. pneumoniae ATCC BAA-1898	KPC-2	2	64	≤0.004
K. pneumoniae ATCC BAA-1899	KPC-2	16	>64	≤0.004
K. pneumoniae ATCC BAA-1900	KPC-3	2	64	≤0.004
K. pneumoniae ATCC BAA-1904	KPC-3	4	>64	≤0.004

^aThe combined concentration of OP0595 was fixed at 4 μg/ml.