TABLE 2.
Effect of OP0595 on the bactericidal activity of cefepime against CTX-M-15-positive E. coli
| Concn of cefepime (μg/ml) | Concn of OP0595 (μg/ml) | No. of strains reaching the indicated decrease in CFU/ml after the period shown |
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2 h |
4 h |
6 h |
24 h |
||||||||||
| 90% | 99% | 99.9% | 90% | 99% | 99.9% | 90% | 99% | 99.9% | 90% | 99% | 99.9% | ||
| Growth control | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
| 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
| 0.25 | 4 | 3 | 3 | 1 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 |
| 1 | 1 | 4 | 2 | 1 | 5 | 5 | 4 | 5 | 5 | 5 | 4 | 4 | 4 |
| 1 | 4 | 4 | 2 | 1 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 |
| 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | |
| 4 | 1 | 0 | 0 | 2 | 0 | 0 | 4 | 2 | 0 | 0 | 0 | 0 | |