TABLE 2.
Population pharmacokinetic parameters of daptomycin
| Parametera,b | Mean value (relative SE)c | Interindividual variability (%)c | Intraindividual variability (%)c |
|---|---|---|---|
| CL (liter/h) | 0.564 (6%) | 5.3 | 22.5 |
| β1(CL, eGFR) | 0.00307 (24%) | NDd | ND |
| β2(CL, sex) | 0.362 (20%) | ND | ND |
| V1 (liters) | 8.43 (9%) | 4.2 | 24.6 |
| β3(V1, sex) | 0.265 (38%) | ND | ND |
| Q (liters/h) | 0.596 (41%) | 71.2 | ND |
| V2 (liters) | 7.17 (40%) | 59.7 | ND |
a
CL, daptomycin plasma clearance; Q, intercompartment clearance; V1, central volume of distribution; V2, volume of the peripheral compartment.
b
Coefficients β quantify the relationships between population parameters (CLpop, V1pop) and covariates as follows: CLpop = 0.564 · exp[β1 · (eGFR/108) + β2 (if male)], where 108 is the median value of eGFR in the study population (ml/min/1.73 m2) and V1pop = 8.43[exp(β3) if male].
c
Relative standard error and interindividual and intraindividual variability are expressed as coefficient of variation (%).
d
ND, not determined.