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. Author manuscript; available in PMC: 2016 May 10.
Published in final edited form as: Cell. 2014 Jan 16;156(1-2):277–290. doi: 10.1016/j.cell.2013.11.044

Figure 6. Myelin compaction from the outer to the inner layers is regulated by MBP and CNP levels.

Figure 6

(A) Cross section of P10 wild-type myelin sheath with outer layers compacted (black arrows) and inner layers non-compacted (white arrows). (B) Amount of myelinated axons with non-compacted layers in wild-type and shiverer heterozygote (Shiv +/-) optic nerves between P10 and P21. (C) Immunoelectron micrograph for MBP of a partially compacted myelin sheath of P10 wild-type optic nerve (black arrows pointing at compacted layers and white arrows to the non-compacted layers). Scale bars= 200nm. Gold size= 10nm. (D) Quantification of MBP labeling per µm of membrane in the compacted and non-compacted layers of P10 wild-type myelin sheaths. (E) Amount of myelinated axons with non-compacted layers in wild-type, Shiv +/-, CNP +/- and CNP -/- at P10. Bars show mean ± SD (n=3-5, 120-200 axons per animal, **p < 0.01, ***p < 0.001, t-test). See also Figure S6.