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. Author manuscript; available in PMC: 2016 May 10.
Published in final edited form as: J Nanomed Nanotechnol. 2016 Jan 25;7(1):350. doi: 10.4172/2157-7439.1000350

Figure 4.

Figure 4

Resveratrol incorporated PLGA scaffolds ameliorated inflammatory genes and upregulated wound healing markers. Gene expression analysis of M1 macrophages on theresveratrol incorporated scaffolds demonstrated (A) IL-6 expression at days 3 to 7, 14 and 21 post-culture. (B) TNF-α expression at days 3 to 7, 14 and 21 post-culture. A single asterisk denotes a significantly higher expression of TNF-α at day 3 compared to the previous time point. (C) IL-10 expression at days 3 to 7, 14 and 21 post-culture. (D) VEGF expression at days 3 to 7, 14 and 21 post-culture. A single asterisk denotes a significantly higher expression of VEGF at day 21. All experiments were done in triplicate. Data points are plotted as mean ± SD (n=3). A single asterisk denotes significantly (P ≤ 0.05) higher as compared to groups denoted by two asterisks. Two asterisks denotes significantly (P ≤ 0.05) higher as compared to groups denoted by three asterisks. Results showed the highest level M2 signatory genes in the presence of resveratrol demonstrating the potential to drive the pro-angiogenic anti-inflammatory response.