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PLP and Cur demonstrated an inhibitory effect on TNF-α secretion by LPS stimulated RAW macrophages with IC50s of respectively 2.6 and 7.4 μM. The other compounds all had an Emax of < 30% and were considered inactive.
| Compound | IC50 (μM) | Emax (%) | Fit (R2) |
|---|---|---|---|
| PLP | 2.6 | 45 | 0.88 |
| EGCG | - | < 30 | - |
| BBCl | - | < 30 | - |
| Cur | 7.4 | 46 | 0.86 |
| Apo | - | < 30 | - |
| Apo-e | 5.2 | 30 | 0.35 |
| PN | - | < 30 | - |
| PTS | - | < 30 | - |
| PSS | - | < 30 | - |
