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PLP, BBCl and Cur demonstrated inhibitory effects on IL-6 secretion in LPS stimulated RAW macrophages with IC50s of respectively 3.7, 10.4 and 22.5 μM. The other compounds all had an Emax of < 30% and were not considered to be inhibitory.
| Compound | IC50 (μM) | Emax (%) | Fit (R2) |
|---|---|---|---|
| PLP | 3.7 | 66 | 0.97 |
| EGCG | - | < 30 | - |
| BBCl | 10.4 | 44 | 0.77 |
| Cur | 22.5 | 100 | 0.84 |
| Apo | - | < 30 | - |
| Apo-e | - | < 30 | - |
| PN | - | < 30 | - |
| PTS | - | < 30 | - |
| PSS | - | < 30 | - |
