Table 4. Inhibition of IL-8 secretion by Caco-2 colon epithelial cells.
EGCG, BBCl and Cur demonstrated inhibitory effects on IL-8 secretion in pro-inflammatory cytokine stimulated Caco-2 cells with IC50s of respectively 78.3, 15.2 and 38.9 μM. The other compounds all had an Emax of < 30% and were not considered to be inhibitory.
| Compound | IC50 (μM) | Emax (%) | Fit (R2) |
|---|---|---|---|
| PLP | - | < 30 | - |
| EGCG | 78.3 | 100 | 0.94 |
| BBCl | 15.2 | 52 | 0.79 |
| Cur | 38.9 | 86 | 0.76 |
| Apo | - | < 30 | - |
| Apo-e | - | < 30 | - |
| PN | - | < 30 | - |
| PTS | - | < 30 | - |
| PSS | - | < 30 | - |