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. 2016 May 10;11(5):e0155372. doi: 10.1371/journal.pone.0155372

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© 2016 Gao et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 9 — Cact and Lwr antagonize Dorsal activity [33–35,45,53], whereas Dorsal represses Ush protein expression. STAT and Srp bind to the ush CRM to activate ush gene expression and thereby maintain Ush protein levels [50,64]. Ush binds to Srp to form a complex that maintains E-cadherin (Ecad) expression. Ecad is required to maintain prohemocyte multipotency and block differentiation [51]. Niche (PSC) in white, MZ prohemocytes are in shades of red, differentiating CZ cells are in shades of grey. The model is a simplification of the total genetic complexity that regulates the prohemocyte population during steady state conditions and does not list all components that control the choice between multipotency and differentiation.