Table 1. Parameter ranges used for the sampling of signalling cycle model.

Parameters	In silico	Measure	Citation
Concentration (μM)	[10−4, 10]	[0.002, 1.8]	[57–63]
Phosphorylation (s−1)	[10−3, 103]	[0.17, 8.87]	[57,59–61]
Dephosphorylation (s−1)	[10−3, 103]	[0.06, 5.31]	[57,59–61]
Protein association (μM−1·s−1)	[10−3, 103]	[0.10, 7.53]	[57,59–61]
Protein disassociation (s−1)	[10−3, 103]	[0.015, 2.86]	[57,59–61]