TABLE 5.

Results of sensitivity analysis summarized for key granuloma outputs and significantly correlated parameters^a

Parameter	Granuloma outcome
	Total CFU		Intracellular CFU		Extracellular CFU		Proportion intracellular		Caseation		Mean O2 in granuloma		TNF:IL-10
	Early	Late	Early	Late	Early	Late	Early	Late	Early	Late	Early	Late	Early	Late
Bacterial
Biomass degradation rate (dmax)	− − − −	− − − −	− − − −	− − − −	− − − −	− − − −	+ + + +	+ + + +	− − − −	− − − −	+	+	− − − −	− − − −
Maximum O2 flux (Vmax,O2)	+ + +	+ + +	+ + +	+ + +	+ + +	+ + +	− − −		+ + +	+ + +			+ + +	+ + +
Environmental
TAG per macrophage (TAGI)	+ +	+ + +			+ +	+ + +	− − −	− − −
Plasma O2 (O2,plasma)	+ +	+ + +	+ +	+ +	+ +	+ + +	− −	− − −	+ +	+ +	+ + + +	+ + + +
O2 vascular permeability (p)			+ +	+ +						+ +	+ + +	+ + +
Macrophage O2 consumption (Vmax−host)											− −	− −

^aKey granuloma outputs are indicated in the table columns and significantly correlated parameters in the table rows. PRCC results are reported as a sign(s) (positive [+] or negative [−]) as well as rank (from strongest correlation [+ + + + or −−−−] to weakest correlation [+ or −]) as determined by z-test results. Significance in PRCC and z-test calculations, alpha = 0.01. Early, <40 dpi; late, >200 dpi.