Cellular response of mouse spleen cells upon reexposure to linocin or OmpW (50 μg/ml). Cytokine levels were measured in restimulated spleen cells from either five linocin-vaccinated mice (gray bars), five OmpW-vaccinated mice (black bars), or five sham-vaccinated mice (PBS controls) (clear bars) following exposure to linocin, OmpW, or PBS, respectively. All mice were cyclophosphamide free. (A) IFN-γ; (B) IL-4; (C) IL-17A; (D) IL-10; (E) IL-6. *, P < 0.05; **, P < 0.01; ***, P < 0.001 (as determined by Student's t test).