Table 2.
Lifespan phenotypes of yeast deletions are significantly conserved. Listed are genes whose deletion in S. cerevisiae was shown to increase RLS in this screen, and whose C. elegans orthologs have been published to have increased lifespan upon deletion, hypomorphic mutation, or RNAi knockdown. poverlap<4E-11; if all ribosomal genes are excluded poverlap<1E-7.
| Worm Orthologs | Yeast Orthologs | Worm Orthologs | Yeast Orthologs | ||||
|---|---|---|---|---|---|---|---|
| ant-1.1 | AAC3 | AAC1 | pps-1 | MET3 | |||
| blmp-1 | MIG1 | pptr-1 | RTS1 | ||||
| cyc-2.1 | CYC1 | rab-5 | VPS21 | ||||
| cyp-13A4 | DIT2 | rpl-19 | RPL19B | ||||
| dod-18 | YOR111W | rpl-34 | RPL34A | RPL34B | |||
| his-71 | HHT1 | rpl-6 | RPL6B | ||||
| idh-1 | IDP1 | rpl-9 | RPL9A | ||||
| ifg-1 | TIF4632 | TIF4631 | rps-11 | RPS11A | |||
| inf-1 | TIF2 | TIF1 | rps-6 | RPS6A | |||
| isw-1 | ISW2 | rps-8 | RPS8A | ||||
| let-363 | TOR1 | sams-1 | SAM1 | ||||
| lgg-1 | ATG8 | sodh-2 | ADH2 | ||||
| nac-2 | nac-3 | PHO87 | spg-7 | AFG3 | |||
| par-5 | BMH2 | spl-1 | DPL1 | ||||
| spt-4 | SPT4 | ||||||