Figure 2. Effects of COX-2 inhibition in the elevated-plus maze.
(A) Effects of LM-4131 (10 mg/kg) and Lumiracoxib (experimental design shown above) under basal non-stressed conditions. (B) Effects of LM-4131 and Lumiracoxib 8 hr after acute foot-shock exposure. Significant F and P values for one-way ANOVA shown above bar graphs. *p<0.05, ****p<0.0001 by Holm-Sidak multiple comparisons post hoc test.
Figure 2—figure supplement 1. Effects of COX-2 inhibition in the EPM in ~4-month-old mice.
(A) Effects of LM-4131 and Lumiracoxib (LMX) in the EPM in ~4-month-old mice under non-stressed conditions. (B) Effects of LM-4131 and LMX in the EPM in 4-month old mice tested 8 hr after foot-shock stress exposure. Significant F and P values for one-way ANOVA shown above figures. *p<0.05, ** p<0.01, ***p<0.001, ****p<0.0001 by Holm-Sidak multiple comparisons post-hoc test.