Figure 3. Effects of COX-2 inhibition on contextual fear conditioning.
(A) Timeline for contextual fear conditioning. Data from each time point shown in correspondingly labeled panel (B–D). (B) No differences in freezing behavior between groups were observed during conditioning. Drugs were administered 6 hr after conditioning (2 hr before fear retrieval). (C) Time course and summary of effects of LM-4131, Lumiracoxib (LMX), or Celecoxib on conditioned fear expression during context re-exposure. (D) Effects of LM-4131, LMX, and Celecoxib on contextual freezing on a second context re-exposure. Significant F and P values for two-way ANOVA (C) and one-way ANOVA (D) shown above figure. *p<0.05, **p<0.01, ***p<0.001, ****p<0.0001 by Holm-Sidak post hoc analysis. Color of * indicates significance level of comparison between each drug and vehicle; red, LM-4131; blue, LMX; green, Celecoxib.