Figure 5. Effects of COX-2 inhibition in the sucrose preference test.
(A–C) 2 hr cumulative sucrose preference, sucrose consumption, and water consumption after vehicle or LM-4131 treatment in non-stressed mice and 8 hr after foot-shock exposure. Testing was conducted during the light phase of the circadian cycle. (D–F) Effects of LM-4131 or vehicle on sucrose preference, sucrose consumption, and water consumption during the light and dark phases of the circadian cycle. Mice were treated with LM-4131 or vehicle 8 hr after foot-shock exposure and tested for 16 hr (4 hr during the light cycle and 12 hr during the dark cycle).