Figure 8. Effects of COX-2 inhibition on ex vivo BLA neuronal excitability.
(A–B) Effects of LM-4131 (10 μM) on BLA neuron excitability, (C) I/V relationship, (D) resting membrane potential (Vm), input resistance (Ri), and action potential (AP) threshold in non-stressed mice. (E–F) Effects of LM-4131 on BLA neuron excitability, (G) I/V relationship, (H) resting membrane potential (Vm), input resistance (Ri), and action potential (AP) threshold in mice 24 hr after foot-shock stress. F and P values for drug effects by two-way ANOVA shown in (A and E), *p<0.05, **p<0.01, ***p<0.001, ****p<0.0001 by post hoc Holm-Sidak test in (A) and (E).
Figure 8—figure supplement 1. Effects of Rimonabant, Apamin, and Capsazepine on LM-4131-induced reductions in BLA neuron excitability.
(A) Effects of Rimonabant (Rim; 5 μM) on LM-4131 (10 μM) induced reductions in BLA neuronal excitability ex vivo. (A) Effects of Capsazepine (CPZ; 10 μM) on LM-4131 induced reductions in BLA neuronal excitability ex vivo. (A) Effects of Apamin (500 nM) on LM-4131 induced reductions in BLA neuronal excitability ex vivo. Drug effect F and P values by two-way ANOVA shown in figures.
Figure 8—figure supplement 2. Effects of FAAH inhibition on ex vivo BLA neuronal excitability.
(A) Effects of PF-3845 on BLA neuron excitability and in non-stressed mice, and (B) 24 hr after foot-chock stress. F and P values for drug effects by two-way ANOVA shown in A and B.