Figure 9. Effects of COX-2 inhibition on in vivo activity of BLA neuronal activity.
(A) LM-4131 decreases latency to enter and increases entries into and time spent in the open arms of the EPM 8 hr following stress exposure. (B) Representative heat maps of time spent in the closed (vertical) versus open (horizontal) arms of the EPM. (C) Percentage of total cells recorded that were responsive upon exiting a closed arm. (D) LM-4131 reduced the maximum firing rate of cells responsive to closed arm exit, but had no effect on cells inhibited by closed-arm exit. (E) LM-4131 reduced the increase in average firing rate following closed arm exit in responsive cells. *p<0.05, **p<0.01 by two-tailed unpaired t-test. F and P values for two-way ANOVA shown in (E).
Figure 9—figure supplement 1. Schematic diagram of in vivo electrophysiological recording sites.
Black dots represent cannula tip locations for vehicle and grey dots represent cannula tip locations for LM-4131 treated mice. Numbers refer to coordinates lateral to bregma for each sagittal brain section.