Table 3.
Predictors of disease-specific and overall survival in T1a gastric cancer patients
| Disease-Specific Survival | Overall Survival | |||||||
|---|---|---|---|---|---|---|---|---|
|
| ||||||||
| Univariate | Multivariate | Univariate | Multivariate | |||||
| HR (95% CI) | P value | HR (95% CI) | P value | HR (95% CI) | P value | HR (95% CI) | P value | |
| Age† | 1.05 (1.03 – 1.07) | <0.01 | 1.05 (1.02 – 1.08) | <0.01 | 1.07 (1.05 – 1.09) | <0.01 | 1.07 (1.05 – 1.09) | <0.01 |
| Median (IQR+) | ||||||||
|
| ||||||||
| Age Group | ||||||||
| 18–64 | (reference) | - | (reference) | - | ||||
| 65–90 | 2.17 (1.23 – 3.81) | 0.01 | 3.00 (2.03 – 4.44) | <0.01 | ||||
|
| ||||||||
| Race/Ethnicity† | ||||||||
| Non-Hispanic White | (reference) | - | (reference) | - | (reference) | - | (reference) | - |
| Black | 1.18 (0.64 – 2.21) | 0.60 | 1.47 (0.76 – 2.83) | 0.25 | 1.01 (0.66 – 1.54) | 0.97 | 1.40 (0.91 – 2.17) | 0.13 |
| Hispanic White | 0.76 (0.38 – 1.55) | 0.45 | 1.00 (0.49 – 2.06) | 0.99 | 0.80 (0.51 – 1.26) | 0.33 | 1.00 (0.63 – 1.58) | 0.99 |
| Asian/Pacific Islanders | 0.39 (0.19 – 0.77) | <0.01 | 0.50 (0.25 – 1.01) | 0.05 | 0.48 (0.32 – 0.72) | <0.01 | 0.60 (0.40 – 0.92) | 0.02 |
|
| ||||||||
| Tumor Location† | ||||||||
| Distal | (reference) | - | (reference) | - | (reference) | - | (reference) | - |
| Proximal | 2.36 (0.91 – 6.13) | 0.08 | 1.94 (0.73 – 5.15) | 0.18 | 1.17 (0.54 – 2.53) | 0.70 | 1.01 (0.46 – 2.21) | 0.97 |
| Middle | 1.22 (0.71 – 2.10) | 0.48 | 1.42 (0.81 – 2.49) | 0.23 | 0.94 (0.66 – 1.34) | 0.73 | 1.05 (0.73 – 1.51) | 0.79 |
| Whole | 0.82 (0.37 – 1.82) | 0.63 | 0.67 (0.30 – 1.51) | 0.34 | 0.97 (0.63 – 1.52) | 0.91 | 0.89 (0.56 – 1.40) | 0.61 |
|
| ||||||||
| Grade† | ||||||||
| Well Differentiated | (reference) | - | (reference) | - | (reference) | - | (reference) | - |
| Moderately Differentiated | 1.96 (0.85 – 4.54) | 0.12 | 1.83 (0.77 – 4.31) | 0.17 | 1.38 (0.85 – 2.23) | 0.19 | 1.41 (0.86 – 2.30) | 0.17 |
| Poorly Differentiated | 1.25 (0.55 – 2.88) | 0.59 | 1.44 (0.60 – 3.45) | 0.41 | 0.75 (0.46 – 1.22) | 0.25 | 1.05 (0.63 – 1.75) | 0.85 |
| Undifferentiated | 1.41 (0.17 – 11.45) | 0.75 | 2.88 (0.34 – 24.56) | 0.33 | 0.95 (0.22 – 4.0.) | 0.94 | 1.91 (0.44 – 8.34) | 0.39 |
| Unknown | 0.83 (0.26 – 2.62) | 0.75 | 0.80 (0.24 – 2.63) | 0.72 | 0.89 (0.48 – 1.63) | 0.70 | 1.15 (0.61 – 2.17) | 0.67 |
|
| ||||||||
| Surgery Type | ||||||||
| Total/Near Total | (reference) | - | (reference) | - | ||||
| Partial | 1.12 (0.55 – 2.26) | 0.75 | 1.31 (0.81 – 2.11) | 0.27 | ||||
|
| ||||||||
| Tumor Size† | ||||||||
| ≤2 cm | (reference) | - | (reference) | - | (reference) | - | (reference) | - |
| >2 cm | 2.13 (1.17 – 3.87) | 0.01 | 1.25 (0.66 – 2.34) | 0.49 | 1.73 (1.20 – 2.50) | <0.01 | 1.16 (0.79 – 1.70) | 0.45 |
| Unknown | 2.68 (1.47 – 4.89) | <0.01 | 2.17 (1.16 – 4.09) | 0.02 | 1.76 (1.20 – 2.59) | <0.01 | 1.51 (1.00 – 2.27) | 0.05 |
|
| ||||||||
| # LN Examined | 0.97 (0.94 – 1.00) | 0.05 | 0.96 (0.94 – 0.98) | <0.01 | ||||
| Median (IQR+) | ||||||||
|
| ||||||||
| # of Examined Nodes† | ||||||||
| 1–14 | (reference) | - | (reference) | - | ||||
| ≥15 | 0.40 (0.21 – 0.76) | <0.01 | 0.53 (0.26 – 1.05) | 0.07 | 0.49 (0.33 – 0.73) | <0.01 | 0.71 (0.47 – 1.08) | 0.11 |
|
| ||||||||
| Positive Node Group† | ||||||||
| 0 | (reference) | - | (reference) | - | (reference) | - | (reference) | - |
| ≥1 | 5.07 (2.97 – 8.67) | <0.01 | 4.58 (2.58 – 8.13) | <0.01 | 2.64 (1.76 – 3.97) | <0.01 | 2.63 (1.70 – 4.06) | <0.01 |
*
Follow-up through December 31, 2012.
†
Included in multivariate model.
^
API=Asian/Pacific Islander