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. 2015 Nov 10;21(10):1358–1365. doi: 10.1038/mp.2015.168

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Copyright © 2015 Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/

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Plasma C-reactive protein (CRP) was negatively associated with functional connectivity between left inferior ventral striatum (iVS) (green seed) and ventromedial prefrontal cortex (vmPFC; BA32, x=−2, y=33, z=−6), with increasing CRP predicting decreasing connectivity (cyan-blue intensity, R=−0.40 to −0.70) in patients with depression (a and b). Z-score maps demonstrated that, whereas patients with high inflammation (CRP>3 mg l⁻¹) exhibited no significant connectivity between left iVS and vmPFC, the subjects with low inflammation (CRP<1 mg l⁻¹) exhibited robust positive connectivity (yellow-red intensity) between these brain regions (c). Clusters are overlaid onto canonical structural brain images in the axial (z=−9: a and c) and sagittal (x=4 and 7: a) planes, corrected P<0.05.