Table 1. Demographic, clinical and inflammatory variables of the study sample and their relationship to the primary variable of inflammation (plasma CRP).
| Variable | Mean (s.d.) (n=48) | Association with CRP (R) | P-valuea |
|---|---|---|---|
| Demographic | |||
| Age (years) | 38.3 (10.9) | −0.12 | 0.400 |
| Sex, Male (n, %) | 14 (29.2) | 0.17 | 0.236 |
| Race | |||
| Caucasian (n, %) | 18 (37.5) | −0.10 | 0.482 |
| African American (n, %) | 30 (62.5) | ||
| Smoking status, yes (n, %) | 8 (16.7) | −0.06 | 0.641 |
| BMI (kg m−2) | 31.2 (7.6) | 0.64 | <0.001*** |
| Clinical | |||
| HAM-D Depression Score | 23.2 (3.2) | 0.25 | 0.091 |
| IDS-SR Anhedonia Score | 4.8 (1.9) | 0.34 | 0.020* |
| SHAPS Score | 5.6 (3.0) | 0.26 | 0.073 |
| Finger Tapping Test, Dominant Hand (mean number taps/10 s) | 40.0 (9.9) | −0.29 | 0.049* |
| Trail Making Test A (s) | 32.6 (14.5) | 0.27 | 0.066 |
| Inflammatory | |||
| CRP (mg l−1) | 2.2 (2.4) | NA | NA |
| IL-6 (pg ml−1) | 1.61 (1.07) | 0.55 | <0.001*** |
| TNF (pg ml−1) | 5.52 (2.23) | 0.06 | 0.708 |
| IL-1beta (pg ml−1) | 0.42 (0.23) | 0.17 | 0.249 |
| IL-6sr (ng ml−1) | 15.75 (3.45) | 0.16 | 0.268 |
| sTNFR2 (ng ml−1) | 2.50 (0.89) | 0.09 | 0.554 |
| IL-1ra (ng ml−1) | 1.61 (2.22) | 0.41 | 0.004** |
Abbreviations: BMI, body mass index; CRP, C-reactive protein; HAM-D, Hamilton Depression Rating Scale; IDS-SR, Inventory of Depressive Symptomatology, Self-Report; IL, interleukin; IL-1ra, IL-1 receptor antagonist; IL-6sr, IL-6 soluble receptor; NA, not applicable; SHAPS, Snaith–Hamilton Pleasure Scale; sTNFR2, soluble tumor necrosis factor receptor 2. *P<0.05, **P<0.01, ***P<0.001.
a
P-value for the correlation with CRP.