Table 2. Ventral and dorsal striatal connectivity was negatively associated with inflammation (plasma CRP) in depression.

Seed ROI	Brain region	mm3	Cluster centroid (MNI)			BA	R-valuea
			x	y	z
iVS
Left	vmPFC/rACC	4327	−2	32	−6	32	−0.56
vrP
Left	vmPFC/mOFC	11 696	1	29	−11	11	−0.56
Right	vmPFC/mOFC	10 005	2	27	−12	11	−0.57
dcP
Left	vmPFC/mOFC	12 913	1	35	−14	11	−0.59
Right	vmPFC/mOFC	16 332	2	36	−13	11	−0.62
dC
Left	vmPFC/mOFC	4190	0	33	−19	11	−0.55
	Right fusiform gyrus	4487	38	−61	−14	37	−0.59
	Left superior frontal gyrus/pre-SMA	1403	−5	17	59	6	−0.53
Right	Left vmPFC/mOFC	3279	−6	35	−16	11	−0.53
	Right fusiform gyrus	1429	35	−56	−18	37	−0.53

Abbreviations: BA, Brodmann area; CRP, C-reactive protein; dC, dorsal caudate; dcP, dorsal caudal putamen; iVS, inferior ventral striatum; MNI, Montreal Neurological Institute and Hospital coordinate system; mOFC, medial orbitofrontal cortex; rACC, rostral anterior cingulate cortex; ROI, region of interest; SMA, supplementary motor area; vmPFC, ventromedial prefrontal cortex; vrP, ventral rostral putamen. Functional connectivity between ventral and dorsal striatum and cortical brain regions that was negatively associated with plasma CRP as determined by whole-brain analysis, voxel-wise P<0.01 plus cluster >1392 mm³: P<0.05 corrected.

^aAll R values remained significant (P<0.05) after adjusting for covariates, including sex, age, race, smoking status, body mass index and depression severity (Hamilton Depression Rating Scale scores).