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. 2016 Jun;68:91–99. doi: 10.1016/j.psyneuen.2016.02.021

Table 3.

Ln(cortisol) on waking and after 30 min (morning rise) on recurrent short sleep and chronic insomnia symptoms.

N = 3064 Recurrent short sleep duration
Chronic insomnia symptoms
Model 1

Model 2

Model 1

Model 2

β (SE) P value β (SE) P value β (SE) P value β (SE) P value
Hours since waking 0.78 (0.18) <0.001 0.75 (0.18) <0.001 0.74 (0.18) <0.001 0.73 (0.18) <0.001
Hours since waking squared −0.77 (0.21) <0.001 −0.77 (0.21) <0.001 −0.76 (0.21) <0.001 −0.76 (0.21) <0.001



Recurrent short sleep (frequency)
No occurrences of short sleep
One occurrence −0.05 (0.04) 0.266 −0.03 (0.05) 0.45
Two occurrences −0.20 (0.07) 0.003 −0.19 (0.07) 0.007
Three occurrences −0.26 (0.08) 0.001 −0.22 (0.08) 0.005



Interaction: hrs since waking × short sleep
No occurrences of short sleep
One occurrence × hours since wakinga −0.00 (0.11) 0.980 −0.03 (0.11) 0.99
Two occurrences × hours since wakingb 0.45 (0.17) 0.008 0.46 (0.17) 0.008
Three occurrences × hours since wakingc 0.35 (0.20) 0.071 0.33 (0.20) 0.08



Chronic insomnia symptoms (frequency)
No occurrences of insomnia symptomsd REF REF
One occurrence −0.02 (0.03) 0.485 −0.01 (0.03) 0.668
Two occurrences −0.03 (0.04) 0.417 −0.01 (0.04) 0.798
Three occurrences −0.13 (0.04) 0.004 −0.10 (0.05) 0.046



Interaction: hrs since waking × insomnia symptoms
No occurrences of insomnia symptoms REF REF
One occurrence × hours since wakinge 0.10 (0.08) 0.191 0.10 (0.08) 0.194
Two occurrences × hours since wakingf 0.02 (0.10) 0.826 0.02 (0.10) 0.833
Three occurrences × hours since wakingg 0.30 (0.11) 0.007 0.30 (0.11) 0.006

Model 1: adjusted for cortisol sample number (dummy variables for whether the cortisol came from first/second sample—estimates of these, compared to the first sample are, 0.14) + waking time, stress of day of sample. Model 2: Model 1 + age, sex, employment grade, smoking, SF-36 Short Form Health Survey (physical and mental component scores) BMI (Body Mass Index), steroids, anti-depressants, sleeping drugs + other sleep exposure.

a

P = 0.50 for one occurrence of short sleep × hours since waking × sex.

b

P = 0.09 for two occurrences of short sleep × hours since waking × sex.

c

P value = 0.25 three occurrences of short sleep × hours since waking × sex.

d

Insomnia symptoms: defined as number of times, across three time points, participant was in fourth quartile of reported insomnia symptoms.

e

P = 0.64 for one occurrence of insomnia symptoms × hours since waking × sex.

f

P = 0.69 for two occurrences of insomnia symptoms × hours since waking × sex.

g

P value = 0.66 three occurrences of insomnia symptoms × hours since waking × sex.