Table 2.
Epigenome-wide association studies in schizophrenia.
| Number of schizophrenic samples | Type of samples | Genes of interest | Chromosome/Locus | References |
|---|---|---|---|---|
| 35 | Frontal cortex post-mortem brain tissue | AUTS2, GRIA2, GLS2, HELT, HCG9, LHX5, LMX1B, JAKMIP1, NR4A2, PLA2G4B, GIRK2, RAI1, SLC17A6, SLC17A7, WD Repeat Domain 18 | 7q11.22, 4q31.1, 12q13.2, 4q35.1, 6p21.33, 12q24.13, 9q33.3, 4p16.1, 2q24.1, 15q15.1, 21q22.13, 17p11.2, 11p14.3, 19q13.33, 19p13.3 | Mill et al., 2008 |
| 44 (monozygotic twins) | Peripheral blood DNA | PUS3, SYNGR2, KDELR1, PDK3, PPARGC1A, ACADL, FLJ90650, TUBB6 | 11q24.2, 17q25.3, 19q13.3, Xp22.11, 4p15.1, 2q34, 5q23.1, 18p11.21 | Dempster et al., 2011 |
| 30 (6 monozygotic twins) | Peripheral blood DNA | PPP1R13L, PVRL4, CRTAP, HSPA1B, DEFB123 | 19q13.32, 1q23.3, 3p22.3, 6p21.3, 20q11.1 | Kinoshita et al., 2013 |
| 18 | Peripheral blood DNA | HTR1E, COMTD1, ADAMTS3 | 6q14.3, 10q22.2, 4q13.3 a | Nishioka et al., 2013 |
| 63 | Peripheral blood DNA | Of 2552 CpG sites, 1161 (45.5%) demonstrated higher DNA methylation | Kinoshita et al., 2014 | |
| 24 | Frontal cortex post-mortem brain tissue | NOS1, AKT1, DNMT1, SOX10, DTNBP1 and PPP3CC | 12q24.22, 14q32.33, 19p13.2, 22q13.1, 6p22.3, 8p21.3 a | Wockner et al., 2014 |
| 39 | Cerebellum | PIK3R1, BTN3A3, NHLH1, SLC16A7 | 5q13.1, 6p22.2, 1q23.2, 12q14.1 | Chen et al., 2014 |
| 20/21 | Frontal cortex post-mortem brain tissue / Cerebellum | GSDMD, RASA3, HTR5A, PPFIA1 | 8q24.3, 13q34, 7q36.2, 11q13.3 a | Pidsley et al., 2014 |
| 2 (2 female monozygotic twins) | Peripheral blood DNA | A) DGKI, DISC1, DRD3, DTNBP1, FXR1, GRIA1, GRIN2B (among 58 other genes for twins from family 1) B) DAOA, DGKI, DISC1, DRD3, IMMP2L, NRG1 (among 13other genes for twins from family 2) | 7q33, 1q42.2, 3q13.31, 6p22.3, 3q26.33, 5q33.2, 12p13.1 13q33.2, 7q31.1, 8p12 | Castellani et al., 2015 |
a
Genome Browser UCSC/hg38 assembly.