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. 2016 May 11;36(19):5241–5251. doi: 10.1523/JNEUROSCI.0499-16.2016

Figure 3.

Figure 3.

Sir2 activity is necessary in the adult brain for normal ethanol response behaviors. A, B, Sedation sensitivity (A) and sedation tolerance (B) in Sir2− flies expressing wild-type Sir2 in the brain. Measurements are presented as the time to 25% sedation due to the marked increase in sedation resistance during exposure 2 in Sir2−;elav>Sir2 (n = 6–8). C, D, Sedation sensitivity (C) and sedation tolerance (D) in flies that have consumed the Sir2 inhibitor nicotinamide (n = 8). E, F, Sedation sensitivity (E) and sedation tolerance (F) in flies expressing Sir2 RNAi under temporal control, limited to adulthood (n = 18), development (n = 7–8), or inhibited through the entire lifespan (n = 6). Error bars indicate the SE. *p < 0.05, **p < 0.01, triangle on temperature shift schematics indicates beginning of adult stage.