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. 2016 Apr 27;2016:8703239. doi: 10.1155/2016/8703239

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Copyright © 2016 Qiu-Ju Jiang et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Pyr 3 partially inhibits ACH-induced contraction. (a) In the presence of nifedipine (10 μM), ACH-induced sustained contraction was partially inhibited by Pyr 3 (a blocker of TRPC3 and STIM/Orai channels) and then was completely blocked by NBAECP. (b) The same experiment was performed in an asthmatic TR. (c) Summary results from 6 control and 7 asthmatic TRs. ^∗ P < 0.05. These results indicated that activation of TRPC3 and/or STIM/Orai channels participated in ACH-induced contraction, and these channels were inhibited by NBAECP, thus resulting in relaxation.