Table 2.
Cytokine levels in the culture medium of MSCs isolated from the bone marrow and skin (pg/mL).
| Group | ||||
|---|---|---|---|---|
| Cytokine | Bone marrow (mean ± SD) | Skin (mean ± SD) | T value | p value |
| Cell proliferation-related cytokines | ||||
| EGF | 52.16 ± 10.75 | 301.35 ± 28.92 | −36.125 | <0.001∗∗ |
| SCF | 99.42 ± 31.08 | 231.55 ± 41.10 | −11.469 | <0.001∗∗ |
| bFGF | 110.09 ± 27.48 | 163.30 ± 53.16 | −3.976 | <0.001∗∗ |
| VEGF | 22.18 ± 7.18 | 590.22 ± 64.68 | −39.037 | <0.001∗∗ |
| M-CSF | 66.99 ± 32.33 | 206.31 ± 42.20 | −11.720 | <0.001∗∗ |
| G-CSF | 60.21 ± 16.70 | 141.13 ± 13.15 | −17.028 | <0.001∗∗ |
| GM-CSF | 167.44 ± 36.38 | 194.73 ± 26.72 | −2.703 | 0.01∗ |
| LIF | 41.62 ± 8.25 | 28.42 ± 10.74 | 4.358 | <0.001∗∗ |
| TGF-β1 | 83.54 ± 35.28 | 395.16 ± 80.27 | −15.894 | <0.001∗∗ |
|
| ||||
| Inflammatory cytokines | ||||
| IL-1 | 65.32 ± 21.71 | 36.29 ± 9.81 | 5.450 | <0.001∗∗ |
| IL-3 | 234.70 ± 34.81 | 67.03 ± 10.79 | 20.574 | <0.001∗∗ |
| IL-6 | 79.63 ± 12.65 | 61.67 ± 17.53 | 3.715 | 0.001∗∗ |
| IL-7 | 90.24 ± 26.70 | 106.11 ± 21.93 | −2.053 | 0.047∗ |
| IL-8 | 55.22 ± 10.69 | 25.03 ± 4.56 | 11.614 | <0.001∗∗ |
| IL-11 | 124.19 ± 25.00 | 181.37 ± 31.74 | −6.330 | <0.001∗∗ |
| HGF | 57.43 ± 7.96 | 319.24 ± 41.03 | −28.016 | <0.001∗∗ |
| TNF-α | 24.26 ± 6.46 | 62.47 ± 12.41 | −12.216 | <0.001∗∗ |
EGF: epidermal growth factor; SCF: stem cell factor; bFGF: basic fibroblast growth factor; VEGF: vascular endothelial growth factor; M-CSF: macrophage colony-stimulating factor; G-CSF: granulocyte colony-stimulating factor; GM-CSF: granulocyte-macrophage colony-stimulating factor; LIF: leukemia inhibitory factor; TGF: transforming growth factor; IL: interleukin; HGF: hepatocyte growth factor; TNF: tumor necrosis factor. ∗ p < 0.05; ∗∗ p < 0.01.