Table 2. Functional annotation clustering of CRE-interacting candidates.
| ANNOTATION CLUSTER | SCORE | ANNOTATION CATEGORY | TERMS | N | P.VALUE | BENJAMINI |
|---|---|---|---|---|---|---|
| Cluster 1 | 15.9 | INTERPRO | RNA recognition motif, RNP-1 | 16 | 1.1E-16 | 1.4E-14 |
| 15.9 | INTERPRO | Nucleotide-binding, alpha-beta plait | 16 | 1.3E-16 | 6.8E-15 | |
| 15.9 | SMART | RRM | 16 | 1.3E-16 | 2.2E-15 | |
| Cluster 2 | 8.87 | GOTERM_BP_FAT | DNA repair | 14 | 2.7E-11 | 1.2E-8 |
| 8.87 | GOTERM_BP_FAT | response to DNA damage stimulus | 14 | 8.0E-10 | 1.2E-7 | |
| 8.87 | GOTERM_BP_FAT | cellular response to stress | 14 | 1.2E-7 | 1.0E-5 | |
| Cluster 3 | 8.81 | GOTERM_CC_FAT | intracellular organelle lumen | 24 | 1.0E-9 | 3.8E-8 |
| 8.81 | GOTERM_CC_FAT | organelle lumen | 24 | 1.6E-9 | 4.6E-8 | |
| 8.81 | GOTERM_CC_FAT | membrane-enclosed lumen | 24 | 2.4E-9 | 5.4E-8 | |
| Cluster 4 | 4.91 | GOTERM_CC_FAT | DNA replication factor A complex | 4 | 7.0E-7 | 8.9E-6 |
| 4.91 | GOTERM_CC_FAT | replisome | 4 | 1.3E-5 | 1.3E-4 | |
| 4.91 | GOTERM_CC_FAT | nuclear replisome | 4 | 1.3E-5 | 1.3E-4 | |
| 4.91 | GOTERM_CC_FAT | nuclear replication fork | 4 | 1.6E-5 | 1.3E-4 | |
| 4.91 | GOTERM_CC_FAT | replication fork | 4 | 1.6E-4 | 1.0E-3 | |
| Cluster 5 | 3.71 | GOTERM_BP_FAT | RNA splicing | 8 | 8.8E-5 | 3.6E-3 |
| 3.71 | GOTERM_BP_FAT | mRNA processing | 8 | 1.9E-4 | 7.0E-3 | |
| 3.71 | GOTERM_BP_FAT | mRNA metabolic process | 8 | 4.4E-4 | 1.3E-2 | |
| Cluster 6 | 3.57 | GOTERM_BP_FAT | RNA splicing, via transesterification reactions | 6 | 2.7E-4 | 9.2E-3 |
| 3.57 | GOTERM_BP_FAT | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 6 | 2.7E-4 | 9.2E-3 | |
| 3.57 | GOTERM_BP_FAT | nuclear mRNA splicing, via spliceosome | 6 | 2.7E-4 | 9.2E-3 | |
| Cluster 7 | 3.42 | KEGG_PATHWAY | Mismatch repair | 4 | 2.0E-4 | 3.0E-3 |
| 3.42 | KEGG_PATHWAY | Homologous recombination | 4 | 3.6E-4 | 3.7E-3 | |
| 3.42 | KEGG_PATHWAY | DNA replication | 4 | 7.6E-4 | 5.9E-3 | |
| Cluster 8 | 3.3 | GOTERM_BP_FAT | nucleotide-excision repair, DNA damage removal | 4 | 7.4E-5 | 3.3E-3 |
| 3.3 | GOTERM_BP_FAT | nucleotide-excision repair | 4 | 1.2E-3 | 2.8E-2 | |
| 3.3 | GOTERM_BP_FAT | DNA catabolic process | 4 | 1.5E-3 | 3.3E-2 |
SCORE, enrichment score of the annotation cluster; N, number of genes involved in the term.