Table 2. Comparison of the mean relative abundance in fecal microbiota of a selection of taxa among the three study groups (CDI, AB+ and AB−).
| Taxa#,♦ | AB− | AB+ | CDI | AB+ vs AB− | p-value* | p-value° | CDI vs AB+ | p-value* | p-value° | CDI vs AB− | p-value* | p-value° |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Salinibacter | 0.14% | 0.00% | 0.00% | −100.00% | 0.75 | – | 0.01 | 0.05 | −97.24% | 0.47 | ||
| Anaerotruncus | 0.87% | 0.43% | 0.03% | −50.20% | 0.07 | −92.79% | 0.06 | −96.41% | 0.03 | 0.16 | ||
| U. m. of Christensenellaceae family | 1.13% | 2.08% | 0.06% | 83.59% | 0.48 | −97.20% | 0.06 | −94.86% | 0.006 | 0.11 | ||
| U. m. of Porphyromonadaceae family | 0.42% | 0.27% | 0.02% | −36.72% | 0.76 | −91.29% | 0.03 | 0.08 | −94.49% | 0.09 | ||
| Barnesiella | 1.27% | 1.03% | 0.11% | −18.73% | 0.68 | −88.97% | 0.02 | 0.08 | −91.04% | 0.01 | 0.10 | |
| Butyricimonas | 0.40% | 0.48% | 0.04% | 21.01% | 0.95 | −92.34% | 0.02 | 0.009 | −90.73% | 0.001 | 0.03 | |
| Collinsella | 0.39% | 0.26% | 0.04% | −33.80% | 0.4 | −85.93% | 0.006 | 0.02 | −90.68% | 0.03 | 0.19 | |
| Lachnospira | 3.28% | 1.22% | 0.31% | −62.84% | 0.23 | −74.81% | 0.19 | −90.64% | 0.005 | 0.06 | ||
| Alistipes | 10.73% | 4.61% | 1.25% | −57.07% | 0.001 | 0.03 | −72.87% | 0.06 | −88.35% | 0.0002 | 0.03 | |
| U. m. of Ruminococcaceae family | 11.20% | 9.76% | 1.82% | −12.81% | 0.29 | −81.39% | 0.002 | 0.01 | −83.77% | <0.001 | 0.003 | |
| Oscillospira | 0.22% | 0.38% | 0.05% | 67.97% | 0.1 | −88.02% | 0.0004 | 0.0009 | −79.88% | 0.0002 | 0.008 | |
| Subdoligranulum | 0.45% | 1.19% | 0.11% | 161.37% | 0.21 | −90.33% | 0.04 | 0.09 | −74.72% | 0.03 | 0.13 | |
| U. m. of Clostridiales order | 0.76% | 1.32% | 0.25% | 74.93% | 0.13 | −81.47% | 0.008 | 0.004 | −67.59% | 0.001 | 0.02 | |
| U. m. of Bacteroidales order | 0.28% | 0.24% | 0.10% | −12.77% | 0.3 | −59.83% | 0.07 | −64.96% | 0.02 | 0.39 | ||
| Bacteroides | 29.59% | 31.33% | 11.86% | 5.89% | 0.61 | −62.15% | 0.002 | 0.01 | −59.92% | 0.004 | 0.07 | |
| U. m. of Lachnospiraceae family | 13.64% | 11.81% | 6.12% | −13.37% | 0.74 | −48.20% | 0.09 | −55.12% | 0.04 | 0.29 | ||
| Bilophila | 0.12% | 0.04% | 0.09% | −63.75% | 0.02 | 0.04 | 105.74% | 0.56 | −25.42% | 0.67 | ||
| Escherichia-Shigella | 0.92% | 0.89% | 10.69% | −3.47% | 0.6 | 1105.91% | 0.55 | 1064.02% | 0.006 | 0.45 | ||
| U. m. of Lactobacillales order | 0.01% | 0.05% | 0.25% | 394.86% | 0.07 | 361.84% | 0.07 | 2185.49% | 0.005 | 0.21 | ||
| U. m. of Gammaproteobacteria class | 0.00% | 0.01% | 0.11% | 144.16% | 0.38 | 928.75% | 0.02 | 0.04 | 2411.74% | 0.002 | 0.03 | |
| Helicobacter | 0.03% | 0.04% | 0.97% | 62.89% | 0.9 | 2149.13% | 0.02 | 0.04 | 3563.49% | 0.03 | 0.17 | |
| U. m. of Enterobacteriaceae family | 0.05% | 0.06% | 2.41% | 20.68% | 0.84 | 3770.70% | 0.02 | 0.006 | 4571.27% | 0.009 | 0.006 | |
| U. m. of Enterococcaceae family | 0.01% | 0.03% | 0.46% | 192.58% | 0.11 | 1623.84% | 0.008 | 0.09 | 4943.66% | 0.02 | 0.38 | |
| Enterococcus | 0.27% | 1.95% | 16.86% | 629.45% | 0.03 | 0.07 | 765.98% | 0.0008 | 0.03 | 6216.91% | 0.0005 | 0.13 |
| Klebsiella | 0.12% | 0.19% | 14.31% | 54.25% | 0.48 | 7429.84% | 0.008 | 0.004 | 11514.90% | 0.002 | 0.003 |
Only taxa with a significant age- and sex-adjusted difference in at least one of the three comparisons (AB+ vs AB−, CDI vs AB+, CDI vs AB−) are reported in this Table. The full Table, including all taxa with an average relative abundance >0.1% in at least one group (77 taxa), is available in Supplemental Material. (CDI: Clostridium difficile infected samples, n = 25; AB+: Clostridium difficile-negative samples, patients exposed to antibiotic treatment, n = 29; AB−: Clostridium difficile-negative samples, patients not exposed to antibiotic treatment, n = 30).
U.m. = Unclassified members.
*Age- and sex-adjusted.
°Fully-adjusted (age, sex, length of hospital stay, number of drugs).
#Taxa in bold show decrease lower than 50% in CDI vs AB− subjects with p-value < 0.005.
♦Taxa underlined show decrease lower than 50% or increase higher than 100% in AB and CDI vs AB− subjects.