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. 2016 May 11;6:25878. doi: 10.1038/srep25878

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Copyright © 2016, Macmillan Publishers Limited

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The main pathway of 3βAdiol production is from testosterone (T). Δ⁴-3-ketosteroid-5α-reductase (5αR) converts T to 5α-dihydrotestosterone (DHT). 17β-hydroxysteroid dehydrogenase type 7 (17βHSD VII) converts DHT to 3βAdiol. 3βAdiol is metabolized by cytochrome P450, family 7, subfamily B, polypeptide 1 (CYP7B1) to 5α-androstane-3β, 7α, 17β-triol (triol). T is synthesized from Δ5-diol (Androstenediol) via 3βHSD, and Δ5-diol is from DHEA (dehydroepiandrosterone) via 17βHSD.