Scatterplots of CSF orexin-A, Aβ42, and the natural log of CSF P-Tau and T-Tau for all subjects are shown. Significant correlations were found between all CSF biomarkers and orexin-A levels. Aβ42, amyloid beta 42; CSF, cerebrospinal fluid; P-Tau, phosphorylated tau; T-Tau, total tau.