Figure 3. CHD GWAS risk genes are active in selective cell types involved in atherosclerosis.

Coronary Heart Disease follow-up studies have demonstrated roles for LIPA, SORT1 and TRIB1 as plasma lipid regulators in the liver, as well as in macrophages biology. Within the vessel wall, TCF21 is upregulated in de-differentiated smooth muscle cells which migrate to the forming fibrous cap. Adamts7 is also a regulator of smooth muscle migration but also a role in endothelial cells has been suggested