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. 2016 May 11;6:25520. doi: 10.1038/srep25520

Figure 2. LPS modulates mRNA expression of molecules in the EBI2 signaling pathway in mouse astrocytes.

Figure 2

(a) Synthetic and degrading pathway of 7α25HC. (b) Treatment of mouse astrocytes with LPS (100 ng/ml) induces a rapid and lasting suppression of EBI2 mRNA expression. (c) LPS induces CH25H mRNA expression in mouse astrocytes that peaks after four to six hours and declines thereafter. (d) LPS induces a slow and gradual increase in CYP7B1 mRNA expression in mouse astrocytes. (e) LPS induces increase in HSD3B7 mRNA expression after 24 hour treatment. Data presented as mean +/− SEM, n = 3, one-way ANOVA and Dunnett’s post-test, *p < 0.05, ***p < 0.001 vs. corresponding control.