Fig 4.

Overexpression of miR-361-3p inhibits NSCLC in vivo. a The NSCLC mouse subcutaneous implantation model in mice was constructed by using A549&HTB-182 cells infected with negative control and miR-361-precursor. Tumor volumes of subcutaneous implantation models of A549 are shown; and tumor volumes in the orthotopic implantation models at week 3or4 are shown. b Tumor volumes of intravenous metastasis models of A549 are shown. c Tumor growth curves of subcutaneous implantation models of NSCLC. d The expression of SH2B1 in local tumor tissues was determined by immunohistochemistry. e The percentage of mice with or without metastatic nodules in the lungs was calculated and compared. Data were represented as the mean ± SEM of three independent experiments. **P < 0.01