Figure 5.

SLAH3 Inhibits KAT1 Significantly, but to a Lesser Extent than Does SLAC1.

(A) to (C) Typical whole-oocyte recordings of negative control oocytes injected with water (A), positive control oocytes expressing KAT1 alone (B), and oocytes coexpressing KAT1 and SLAH3 in a [cRNA] ratio of KAT1/SLAH3 of 1:2 (C).

(D) Average current-voltage curves of steady state whole-oocyte currents recorded in the negative control (n = 5), positive control (n = 10), and oocytes coexpressing KAT1 and SLAH3 (n = 7).

(E) Normalized macroscopic conductance and immunoblot analysis. The oocyte numbers in (E) were the same as described for (D).

(F) Co-IP data showing protein-protein interaction between SLAH3 and KAT1. Error bars depict means ± se.