Table 1. - Variables with association with the time until occurrence of dry eye. Belo Horizonte, MG, Brazil, 2014.

Variables	Group	Dry eye	Hazard Ratio (HR) (CI 95%)	p value
		Yes		No
		n	%		n	%
Sedation	No	51	41.8		96	88,9	2.10 (1.46 - 3.02)	< 0.001
	Yes	71	58.2		12	11.1
Intubation	No	27	22.1		93	86.1	3.16 (2.06 - 4.85)	< 0.001
	Yes	95	77.9		15	13.9
Mechanical Ventilation	No	24	19.7		92	85.2	3.40 (2.17 - 5.32)	< 0.001
	Yes	98	80.3		16	14.8
O2 on room air	No	116	95.1		50	46.3	0.12 (0.05 - 0.29)	< 0.001
	Yes	6	4.9		58	53.7
O2 by nasal catheter	No	103	84.4		46	42.6	0.27 (0.16 - 0.44)	< 0.001
	Yes	19	15.6		62	57.4
Oral diet allowed	No	62	50.8		37	34.3	0.43 (0.30 - 0.63)	< 0.001
	Yes	60	49.2		71	65.7
Feeding tube	Enteral feeding	45	75.0		11	15.5	3.01 (1.64 - 5.49)	< 0.001
Blinking	Up to five times per minute	101	82.8		11	10.2	0.16 (0.10 - 0.26)	< 0.001
	More than five times per minute	21	17.2		97	89.8
Eyeball exposure	No	62	50.8		104	96.3	2.43 (1.70 - 3.48)	< 0.001
	Yes	60	49.2		4	3.7
Oedema	No	12	9.8		40	37.0	2.39 (1.31 - 4.34)	0.004
	Yes	110	90.2		68	63.0
Oedema site	Chemosis - left eye	45	36.9		9	8.3	1.79 (1.24 - 2.59)	0.002
	Chemosis - right eye	45	36.9		9	8.3	1.79 (1.24 - 2.59)	0.002
	MMII	70	57.4		34	31.5	1.47 (1.03 - 2.11)	0.033
	Anasarca	9	7.4		1	0.9	3.05 (1.53 - 6.09)	0.001
Anticoagulants	Yes	82	67.2		84	77.8	0.64 (0.43 - 0.93)	0.022
Hypnotics/sedatives/anxiolytics	Yes	71	58.2		20	18.5	1.58 (1.10 - 2.27)	0.013
Antihypertensives	Yes	19	15.6		32	29.6	0.53 (0.32 - 0.87)	0.013
Analgesic	Yes	22	18.0		43	39.8	0.62 (0.39 - 0.99)	0.048
SOFA*†	Yes	6.8	3.7		4.0	3.5	1.10 (1.05 - 1.15)	< 0.001
APACHE II*‡	Yes	25.4	7.5		19.0	9.7	1.03 (1.01 - 1.04)	< 0.001
TISS 28*§	Yes	35.8	8.1		26.7	8.7	1.06 (1.03 - 1.08)	< 0.001
Postoperative time*	Yes	2.9	1.0		2.6	1.1	0.44 (0.31 - 0.63)	< 0.001
Hospitalization Time*	Yes	3.0	0.9		2.8	1.2	0.05 (0.02 - 0.13)	< 0.001
Glasgow Coma Scale*	Yes	8.9	4.2		14.2	1.3	0.84 (0.80 - 0.89)	< 0.001
Mechanical Ventilation Time*	Yes	3.2	1.2		2.1	1.0	0.64 (0.50 - 0.82)	< 0.001
O2 flow catheter*	Yes	2.3	1.4		1.6	0.7	1.41 (1.01 - 1.97)	0.039
Anticoagulants*	Yes	82	67.2		84	77.8	0.64 (0.43 - 0.93)	0.022
Hypnotics/sedatives/anxiolytics*	Yes	71	58.2		20	18.5	1.58 (1.10 - 2.27)	0.013
Antihypertensives*	Yes	19	15.6		32	29.6	0.53 (0.32 - 0.87)	0.013
Fluid balance/Daily developments (Positive)*	Yes	894.3	978.1		595.2	1022.0	1.00 (1.000003 - 1.0004)	0.046

*Variables in which n corresponds to the mean and % to the standard deviation †SOFA - Sepsis-related Organ Failure Assessment ‡APACHE II - Acute Physiology and Chronic Health disease Classification System II §TISS 28 - Therapeutic Intervention Scoring System