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. Author manuscript; available in PMC: 2016 May 11.
Published in final edited form as: J Clin Immunol. 2010 Sep 28;31(1):39–50. doi: 10.1007/s10875-010-9464-8

Figure 2.

Figure 2

Localization of pro-IL-16 and mature IL-16 in malignant versus normal T cells. The N-terminal antibody (green) recognizes the pro-form of IL-16, whereas the C-terminal antibody (red) recognizes both the pro- and mature cleaved forms of IL-16. Donors 1 and 2 are normal and display nuclear pro-IL-16 and cytoplasmic mature IL-16. Stage IA SS patients demonstrate reduced nuclear pro-IL-16 staining when compared to normal donors. Stage II SS patients no longer display nuclear localization of pro-IL-16. No nuclear translocation of IL-16 after stage II was observed. The images shown are the most representative ones taken from at least three patient samples.