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. Author manuscript; available in PMC: 2016 May 11.
Published in final edited form as: J Clin Immunol. 2010 Sep 28;31(1):39–50. doi: 10.1007/s10875-010-9464-8

Figure 3.

Figure 3

Figure 3

Figure 3

Loss of surface CD26 correlates with disease stage and loss of intracellular IL-16.

A) Loss of surface CD26 was determined by flow cytometry. Cells were gated on CD3 then analyzed for CD26 expression. Number of donors: normal = 4, stage IA = 2, stage IA/B = 3, stage IB = 6, stage II = 2, stage III = 2, stage IV = 5.

B) Demonstration of concordant loss of both intracellular IL-16 and surface CD26. Together with disease stage, we observed losses in both intracellular IL-16 and surface CD26. Quadrant gates were created based on isotype controls from individual experiments.

C) Correlation of loss of intracellular IL-16 and surface CD26 (correlation coefficient = 0.403; P=0.002). Number of donors: normal = 5, stage IA = 2, stage IA/B = 3, stage IB = 6, stage II = 1, stage III = 2, stage IV = 5.