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Time course of the effect of ProTx-II on the thermal nociceptive threshold in diabetic (A) and nondiabetic (B) mice.
Notes: The antinociceptive effect of ProTx-II was assessed in the tail-flick test 30, 60, 90, 120, and 180 minutes after intrathecal injection. Each point represents the mean with standard error of 7–10 mice. *P<0.05 versus respective vehicle (saline)-treated group.
