Figure 2.

Effect of ipamorelin (1 µM) and ghrelin (1 µM) on gastric smooth muscle contractility induced by ACh at 100 µM isolated from a rat model of POI.

Notes: Traces above the histogram represent the contractile response to ACh. Compared to non-POI controls, POI in VEH-treated rats inhibited gastric smooth muscle contractility induced by ACh. Ipamorelin and ghrelin normalized the contractile response to ACh. Data are mean ± SEM for 10 to 11 experiments in each group. Statistical significance was assessed by one-way analysis of variance with Bonferroni posttest comparisons. *P < 0.05; **P < 0.01; ***P < 0.001 compared to POI+VEH-treated tissue.

Abbreviations: ACh, acetylcholine; POI, postoperative ileus; VEH, vehicle.