Table 4.

Citicoline and cognitive function

Reference	Title	Main results	Study type	Patients randomized
Secades29	Citicoline: pharmacological and clinical review, 2010 update	A neuroprotective effect of citicoline; it improves cognitive performance in healthy patients and in patients with dementia	Review	NA
Alvarez-Sabín and Román50	Citicoline in vascular cognitive impairment and vascular dementia after stroke	A neuroprotective effect of citicoline; it improves cognitive performances in healthy patients and in patients with dementia	Review	NA
Vale37	Current management of cognitive dysfunction in Parkinson’s disease: how far have we come?	The author proposes use of citicoline in Parkinson’s dementia	Meta analysis	NA
Parnetti et al24	Cholinergic precursors in treatment of cognitive impairment of vascular origin: ineffective approaches or need for re-evaluation?	The data suggest citicoline improves cognitive performances in patients with dementia (of neurodegenerative and vascular origin)	Review	NA