Table 1.
The Whole Genomes of Nine Highly Aggressive, Treatment-Naive Primary Prostate Tumors and One Nodal Metastasis Were Sequenced
| Sample | Gleason Score | Age at Diagnosis | PSA at Diagnosis (ng/dL) | Germline Cov. | Tumor Cov. | Est. Purity (%)a | Est. Ploidy |
|---|---|---|---|---|---|---|---|
| MC-1T | 9 | 60 | 5.1 | 52.1 | 101.5 | 49 | 2.14 |
| MC-2T | 8 | 68 | 7.1 | 48.1 | 87.5 | 51 | 1.96 |
| MC-3T | 9 | 54 | 17.5 | 48.4 | 98.5 | 56 | 2.1 |
| MC-4T | 9 | 77 | 17.7 | 50.5 | 97.7 | 50 | 2.15 |
| MC-5T | 9 | 62 | 4.4 | 52.2 | 100.3 | 79 | 2.08 |
| MC-6T | 10 | 76 | 15.2 | 46.9 | 103.5 | 50 | 2.19 |
| MC-7T | 9 | 56 | 7.93 | 45.5 | 96.2 | 62 | 2.22 |
| MC-8T | 9 | 66 | 11.14 | 48.2 | 82.5 | 59 | 2.25 |
| MC-9T | 8 | 54 | 7.68 | 45.7 | 92.2 | 75 | 1.96 |
| MC-10M | 7b | 63 | 22.3 | 45.1 | 93.1 | 75 | 2.51 |
| MEAN | – | 63.6 | 11.6 | 48.3 | 95.3 | 60.6 | 2.2 |
Additional clinical information and sequencing metrics can be found in Tables S1 and S2. Purity and ploidy were estimated with Patchwork.24
a
All tumors were macrodissected to target at least 70% Gleason grade 4+ cytoarchitecture, and the purity estimate reported here is the actual purity calculated from sequencing data.
b
For MC-10M, the Gleason score refers to the primary tumor, while the sequenced DNA was isolated from a nodal metastasis.