Table 1.

The significantly enriched GO terms by the differentially expressed genes in bladder cancer

Term	Count	P-value	FDR
A: downregulated
GO:0007155 – cell adhesion	128	6.08E-20	1.11E-16
GO:0030198 – extracellular matrix organization	32	4.15E-11	7.55E-08
GO:0001501 – skeletal system development	61	1.62E-10	2.94E-07
GO:0009719 – response to endogenous stimulus	68	3.96E-09	7.21E-06
GO:0009725 – response to hormone stimulus	62	1.67E-08	3.04E-05
GO:0019226 – transmission of nerve impulse	60	1.70E-08	3.10E-05
GO:0007517 – muscle organ development	43	1.71E-08	3.11E-05
GO:0007167 – enzyme linked receptor protein signaling pathway	58	4.49E-08	8.17E-05
GO:0006873 – cellular ion homeostasis	61	8.13E-08	1.48E-04
GO:0035295 – tube development	42	1.71E-07	3.11E-04
GO:0030182 – neuron differentiation	66	4.55E-07	8.28E-04
GO:0042127 – regulation of cell proliferation	101	9.09E-07	1.66E-03
GO:0001944 – vasculature development	44	9.58E-07	1.74E-03
GO:0007242 – intracellular signaling cascade	145	1.62E-06	2.94E-03
GO:0048878 – chemical homeostasis	72	1.76E-06	3.21E-03
B: upregulated
GO:0007049 – cell cycle	123	1.54E-14	2.77E-11
GO:0000278 – mitotic cell cycle	75	2.06E-14	3.74E-11
GO:0000087 – M phase of mitotic cell cycle	54	1.13E-13	2.05E-10
GO:0051301 – cell division	59	3.02E-11	5.47E-08
GO:0006259 – DNA metabolic process	77	1.51E-08	2.73E-05
GO:0006260 – DNA replication	40	1.56E-08	2.82E-05
GO:0000075 – cell cycle checkpoint	23	1.22E-06	2.21E-03
GO:0051726 – regulation of cell cycle	52	1.72E-06	3.11E-03
GO:0007059 – chromosome segregation	21	2.60E-06	4.71E-03

Abbreviations: FDR, false discovery rate; GO, gene ontology; DNA, deoxyribonucleic acid.