FIG 3 .

Changes in splenic architecture upon infection. (A) Reconstructed spleen cast images. Splenic vein and artery are shown by the yellow arrows (see also Fig. S2 in the supplemental material). (B) Ratios of vein to artery diameters. Data are means ± standard errors of the means (SEM) for results from the three main pairs of veins and arteries of one representative spleen cast of three samples per group. (C) Quantification of the venous branches in spleen casts. Data are from one representative spleen cast of three samples per group. (D) Expression of VEGF in mouse serum. Data are means ± SEM results from a total of five serum samples per group, collected in two replicate experiments.