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. 2016 May 5;98(5):843–856. doi: 10.1016/j.ajhg.2016.03.017

Figure 5.

Figure 5

Massive Rearrangements Are Often Associated with Upregulation of Oncogenes

(A) The frequencies of massively rearranged chromosomes normalized by the uniquely mappable size of CDS in each chromosome.

(B) The frequencies of massively rearranged chromosomes colored by tumor type.

(C) Examples of two breast cancers with massively rearranged chr17. Blue and red lines denote intra-chromosomal and inter-chromosomal rearrangements, respectively.

(D) The breakpoint distribution of massively rearranged chr17 of breast cancers with the peak at ERBB2.

(E) Association (Wilcoxon one-side rank test) of massive rearrangements with copy change and expression of ERBB2 in breast cancers. NMR, not massively rearranged; MR, massively rearranged. Error bars indicate SD.

(F) An example of massively rearranged chr22 that involves chr5 in melanoma.

(G) Association (Wilcoxon one-side rank test) of massively rearranged chr22 with TERT expression. Group 1 includes melanomas with massively rearranged chr22 that involves chr5. Group 2 includes melanomas with massively rearranged chr22 that does not involve chr5 with wild-type TERT promoter. Error bars indicate SD.