Table 2.
Activating Fusions with 3′ Tyrosine Protein Kinases
| ID | Chr A | Breakpoint A | Gene A | Chr B | Breakpoint B | Gene B | Discord Pair | Split Read | Homology |
|---|---|---|---|---|---|---|---|---|---|
| THCA-FK-A3SE | 10 | 61655977 | CCDC6 | 10 | 43611997 | RET | 13 | 17 | 3 |
| THCA-EL-A3ZS | 10 | 61659539 | CCDC6 | 10 | 43611930 | RET | 4 | 4 | 0 |
| THCA-BJ-A0ZJ | 10 | 61626050 | CCDC6 | 10 | 43611953 | RET | 13 | 5 | 1 |
| THCA-ET-A3DQ | 9 | 115932783 | FKBP15 | 10 | 43610457 | RET | 5 | 2 | −3 |
| LUAD-67-6215 | 2 | 42491894 | EML4 | 2 | 29447037 | ALK | 6 | 5 | 2 |
| THCA-EM-A4FR | 5 | 41038833 | MROH2B | 2 | 29481156 | ALK | 7 | 7 | 3 |
| GBM-06-5418 | 6 | 118801608 | CEP85L | 6 | 117642526 | ROS1 | 55 | 46 | −4 |
| BRCA-AR-A0U3 | 19 | 52383621 | ZNF577 | 8 | 38317439 | FGFR1 | 104 | 29 | −7 |
| BRCA-AR-A0TT | 19 | 16243092 | RAB8A | 19 | 4115139 | MAP2K2 | 45 | 32 | 0 |
| GBM-06-5411 | 1 | 204951828 | NFASC | 1 | 156844167 | NTRK1 | 534 | 398 | 2 |
| LGG-E1-5319 | 1 | 155784108 | GON4L | 1 | 156813488 | INSRR | 29 | 24 | 1 |
Genes on the left denoted by “Gene A” are 5′ fusion partners, and genes on the right denoted by “Gene B” are 3′ fusion partners.