Table 3.
Summary of reasons for stopping prior MPH treatment, by treatment (full-analysis set)
| Reason for stopping prior MPH, n (%)a | RCT |
RWS |
|||
|---|---|---|---|---|---|
| Placebo (n=111) |
GXR (n=114) |
ATX (n=112) |
Total (n=337) |
GXR (n=503) |
|
| Number of participants (n) | 48 | 46 | 48 | 142 | 224 |
| Not effective | 28 (58.3) | 25 (54.3) | 27 (56.3) | 80 (56.3) | 145 (64.7) |
| Did not work | 7 (14.6) | 6 (13.0) | 9 (18.8) | 22 (15.5) | 28 (12.5) |
| Effect did not last long enough | 7 (14.6) | 7 (15.2) | 9 (18.8) | 23 (16.2) | 40 (17.9) |
| Was not optimal per the participant/parent/caregiver | 19 (39.6) | 18 (39.1) | 18 (37.5) | 55 (38.7) | 91 (40.6) |
| Was not optimal per the participant’s physician | 8 (16.7) | 7 (15.2) | 14 (29.2) | 29 (20.4) | 31 (13.8) |
| Other | 1 (2.1) | 2 (4.3) | 0 | 3 (2.1) | 13 (5.8) |
| Because the ADHD medication had side effects | 18 (37.5) | 18 (39.1) | 17 (35.4) | 53 (37.3) | 122 (54.5) |
| Wanted to switch to another medication | 15 (31.3) | 15 (32.6) | 11 (22.9) | 41 (28.9) | 12 (5.4) |
| Wanted to stop taking MPH | 7 (14.6) | 8 (17.4) | 9 (18.8) | 24 (16.9) | 25 (11.2) |
| Could not afford to pay for medication | 1 (2.1) | 4 (8.7) | 1 (2.1) | 6 (4.2) | 10 (4.5) |
| Wanted to stop taking any ADHD medication | 0 | 2 (4.3) | 2 (4.2) | 4 (2.8) | 1 (0.4) |
| Wanted to switch to nonpharmacological interventions to treat ADHD | 0 | 0 | 0 | 0 | 0 |
| Other | 1 (2.1) | 0 | 0 | 1 (0.7) | 13 (5.8) |
Notes: Reasons for stopping previous MPH treatment were recorded in the Prior Stimulant Medication Questionnaire.
a
Categories not mutually exclusive; therefore, columns may total >100%. Includes participants who took prior MPH, as confirmed by medical review of medication names provided in the questionnaire. Percentages based on the number of participants who took prior MPH in the respective subgroups.
Abbreviations: ADHD, attention-deficit/hyperactivity disorder; ATX, atomoxetine; GXR, guanfacine extended release; MPH, methylphenidate; RCT, randomized controlled trial; RWS, randomized-withdrawal study.